ZHOU LAB
Publication

Publication

2024

  • Zhao H, Liu Z, Chen H, Han M, Zhang M, Liu K, Jin H, Liu X, Shi M, Pu W, Werner M, Meister M, Kauschke S, Sun R, Wang J, Shen R, Wang Q, Ma X, Thors J, Zhou B*. Identifying specific functional roles for senescence across cell types. Cell 2024, doi.org/10.1016/j.cell.2024.09.021. PDF
  • Liu K, Meng X, Liu Z, Tang M, Lv Z, Huang X, Jin H, Han X, Liu X, Pu W, Zhu H, Zhou B*. Tracing the origin of alveolar stem cells in lung repair and regeneration. Cell 2024;187:2428-2445. PDF
  • Lv Z, Liu Z, Liu K, Lin X, Pu W, Li Y, Zhao H, Xi Y, Sui P, Vaughan A, Gillich A, Zhou B*. Alveolar regeneration by airway secretory cell-derived p63+ progenitors. Cell Stem Cell 2024;31:1685-1700.e6.
  • Guo W, Zhang X, Li L, Shao P, Liang C, Zhang H, Liu K, Wang S, Peng Y, Luo J, Ju Y, De Marzo A*, Yu C*, Chen L*, Zhou B*, Gao D*. JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination. Nat Genet 2024 10.1038/s41588-024-01979-1.
  • Li Y, Liu Z, Han X, Liang F, Zhang Q, Huang X, Shi X, Huo H, Han M, Liu X, Zhu H, He L, Shen L, Hu X, Wang J, Wang Q, Smart N, Zhou B*, He B*. Dynamics of Endothelial Cell Generation and Turnover in Arteries during Homeostasis and Diseases. Circulation 2024;149:135-154.
  • Zhang M, Lui K*, Zhou B*. Application of New Lineage Tracing Techniques in Cardiovascular Development and Physiology. Circ Res 2024;134:445-458.
  • Yang G*, He Q, Guo X, Li RY, Lin J, Lang Y, Tao W, Liu W, Lin H, Xing S, Qi Y, Xie Z, Han JJ, Zhou B*, Teng Y*, Yang X*. Identification of the metaphyseal skeletal stem cell building trabecular bone. Sci Adv 2024;10:eadl2238.
  • Shi M, Li J, Liu X, Liu K, Pu W, Weng W, Zhang S, Zhao H, Lui K, Zhou B*. The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo. ELife 2024 doi.org/10.7554/eLife.97717.
  •  Liu K, Zhang S, Meng X, Li H, Zhu J, Wang E, Tang M, Zhang M, Zhou B*, Wang L*. Intercellular genetic tracing by alternative synthetic Notch signaling. Cell Discov 2024;10(1):101.
  • Li H, Zhang S, Huang X, Zhang Z, Liu K, Wang Q, Chen A, Lui K, Sun K, Zhou B*. Genetic recording of transient endothelial activation in distinct alveolar capillary cells during pulmonary fibrosis. Cell Discov 2024;10(1):119.

2023

  • Pu W, Zhu H, Zhang M, Pikiolek M, Ercan C, Li J, Huang X, Han X, Zhang Z, Lv Z, Li Y, Liu K, He L, Liu X, Heim MH, Terracciano L, Tchorz JS*, Zhou B*. Bipotent transitional liver progenitor cells contribute to liver regeneration. Nat Genet 2023;55(4):651-664. Cover Story. PDF
  • Han M, Z L, Liu L, Huang X, Wang H, Pu W, Wang E, Liu X, Li Y, He L, Li X, Wu J, Qiu L, She R, Wang Q, Ji Y, Ardehali R, Shu Q, Lui KO, Wang L, Zhou B*. Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis. Nat Genet 2023;55(4):665-678. PDF
  • Liu K*, Jin H, Zhang S, Tang M, Meng X, Li Y, Pu W, Lui K, Zhou B*. Intercellular genetic tracing shows the lack of hematopoietic specification from cardiac endothelium in the developing heart. Dev Cell 2023;58(16):1502-1512.
  • Wu J, Zhao H, Tao Y, Yang C, Yang Y, Zhou B*, Zhao Y*. Improved Factor Combination for In  Vivo Reprogramming of Cardiac Myofibroblast to Cardiomyocyte-Like Cell With Dual Recombinase Tracing. Circulation 2023;148:1728-1731.
  • Zhang S, Zhang Q, Liu Z, Liu K, He L, Lui KO, Wang L*, Zhou B*. Genetic dissection of intercellular interactions in vivo by membrane-permeable protein. PNAS 2023;120(1):e2120582120.
  • Liu K, Tang M, Xu W, Meng X, Jin H, Han M, Pu J, Li Y, Jiao F, Sun R, Shen R, Lui K, Lu L*, Zhou B*. An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo. PNAS 2013;120(25):e2207210120.
  • Liu X, Weng W, He L*, Zhou B*. Genetic recording of in vivo cell proliferation by ProTracer. Nat Protoc 2023;18:2349-2373. Cover Story.
  • Zhao H, Huang X, Liu Z, Lai L, Sun R, Shen R, Li Y, He L, Pu W, Lv Z, Li Y, Han X, Liu X, Zhou B*. Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas. Cell Discov 2023;9:1.
  • Zhang M, Pu W, Li J, Han M, Han X, Zhang Z, Lv Z, Smart N, Wang L*, Zhou B*. Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart. Cell Discov 2023;9:9

2022

  • Zhang S, Zhao H, Liu Z, Liu K, Zhu H, Pu W, He L, Wang R, Zhou B*. Monitoring of cell-cell communication and contact history in mammals. Science 2022;378(6623): eabo5503. PDF
  • Pu W, Zhang M, Liu X, He L, Li J, Han X, Lui KO, He B, Zhou B*. Genetic Proliferation Tracing Reveals a Rapid Cell Cycle Withdrawal in Preadolescent Cardiomyocytes. Circulation 2022;145:410-412.
  • Han M, Liu Z, He L, Li X, Liu L, Huang X, Zhang M, Yan Y, Lui KO, Zhou B*. Dual Genetic Lineage Tracing Reveals Capillary to Artery Formation in the Adult Heart. Circulation 2022;145:1179-1181.
  • Tang J, Zhu H, Tian X, Wang H, Liu S, Liu K, Zhao H, He L, Huang X, Feng Z, Ding Z, Long B, Yan Y, Smart N, Gong H, Luo Q, Zhou B*. Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates. Circ Res 2022;130:352-365. (Cover story)
  • Jin H, Liu K, Huang X, Huo H, Mou J, Qiao Z, He B, Zhou B*. Genetic Lineage Tracing of Pericardial Cavity Macrophages in the Injured Heart. Circ Res 2022;130:1682-1697. (Cover story)
  • Liu K, Jin H, Tang M, Zhang S, Tian X, Zhang M, Han X, Liu X, Tang J, Pu W, Li Y, He L, Yang Z, Lui K, Zhou B*. Lineage tracing clarifies the cellular origin of tissue resident macrophages in the developing heart. J Cell Biol 2022;221:e202108093.
  • Wang H, He L, Li Y, Pu W, Zhang S, Han X, Lui K, Zhou B*. Dual recombinases mediate synchronized lineage tracing and cell subset ablation in vivo. J Bio Chem 2022;298:101965.

2021

  • He L, Pu W, Liu X, Zhang Z, Han M, Li Y, Huang X, Han X, Li Y, Liu K, Shi M, Lai L, Sun R, Wang Q, Ji Y, Tchorz J, Zhou B*. Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science 2021;371:eabc4346. Research Article. PDF
  • Han X, Zhang Z, He L, Zhu H, Li Y, Pu W, Han M, Zhao H, Liu K, Li Y, Huang X, Zhang M, Jin H, Lv Z, Tang J, Wang J, Sun R, Fei J, Tian X, Duan S, Wang Q, Wang L, He B, Zhou B*. A suite of new Dre-recombinase drivers markedly expans the ability to perform intersection genetic targeting. Cell Stem Cell 2021;28:1-17 PDF
  • Zhao H, Huang X, Liu Z, Pu W, Lv Z, He L, Li Y, Zhou Q, Lui KO, Zhou B*. Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas. Nat Metab 2021;3(3):352-365. PDF
  • Wang H, Zhao H, Zhu H, Li Y, Tang J, Li Y, Zhou B*. Sca1+ Cells Minimally Contribute to Smooth Muscle Cells in Atherosclerosis. Circ Res 2021;128:133-135.
  • Liu X, Pu W, He L, Li Y, Zhao H, Li Y, Liu K, Huang X, Weng W, Wang Q-D, Shen L, Zhong T, Sun K, Ardehali R, He B*, Zhou B*. Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle. Nat Commun 2021;12(1):5784.
  • Jin H, Liu K, Tang J, Huang X, Wang H, Zhang Q, Zhu H, Li Y, Pu W, Zhao H, He L, Li Y, Zhang S, Zhang Z, Zhao Y, Qin Y, Pflanz S, Kasmi K, Zhang W, Liu Z, Ginhoux F, Ji Y, He B, Wang L, Zhou B*. Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Nat Commun 2021; 12(1): 2863.
  • Zhang S, Li Y, Huang X, Liu K, Wang QD, Chen AF, Sun K, Lui KO, Zhou B*. Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells During Cardiac Fibrosis. Circulation 2021;144:2004-2020.
  • Li Y, Zhu H, Zhang Q, Han X, Zhang Z, Shen L, Wang L, Lui KO, He B, Zhou B*. Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque. Cell Discov 2021;7:111.
  • Tang J, Zhu H, Liu S, Wang H, Huang X, Yan Y, Wang L, Zhou B*. Sca1 marks a reserve endothelial progenitor population that preferentially expand after injury. Cell Discov 2021;7.
  • Tian X, Zhou B*. Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution. J Biol Chem 2021;296:100509.
  • Weng W, Liu X, Lui KO, Zhou B*. Harnessing orthogonal recombinases to decipher cell fate with enhanced precision. Trends Cell Biol 2021S0962-8924(21)00186.
  • Zhao H, Lui KO, Zhou B*. Pancreatic beta cell neogenesis: Debates and updates. Cell Metab 2021;33:2105-2107.
  • Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B*. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature 2021;592:606-610.

2020

  • Tang J, Wang H, Huang X, Li F, Zhu H, Li Y, He L, Zhang H, Pu W, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Tian X, Zhang L*, Gao D*, Zhou B*. Arterial Sca1+ Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration. Cell Stem Cell 2020;26:81-96.e4. PDF
  • Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B*. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 2020;54:593-607.e5. (Featured Article) PDF
  • He L, Nguyen NB, Ardehali R*, Zhou B*. Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress. Circulation 2020;142:275-291.
  • Zhao H, Li Y, He L, Pu W, Yu W, Li Y, Wu YT, Xu C, Wei Y, Ding Q, Song BL, Huang H*, Zhou B*. In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia. Circulation 2020;141:67-79.
  • Han M, Zhou B*. Sox17 and Coronary Arteriogenesis in Development. Circ Res 2020;127:1381-1383.
  • Wang Z, Zheng Y, Wang F, Zhong J, Zhao T, Xie Q, Zhu T, Ma F, Tang Q, Zhou B*, Zhu J*. Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier. Science Advances 2020;6:eaay8627.
  • Pu W, Han X, He L, Li Y, Huang X, Zhang M, Lv Z, Yu W, Wang QD, Cai D, Wang J, Sun R, Fei J, Ji Y, Nie Y, Zhou B*. A genetic system for tissue-specific inhibition of cell proliferation. Development 2020;147:dev183830.
  • Tian X, He L, Liu K, Pu W, Zhao H, Li Y, Liu X, Tang M, Sun R, Fei J, Ji Y, Qiao Z, Lui KO, Zhou B*. Generation of a self-cleaved inducible Cre recombinase for efficient temporal genetic manipulation. EMBO J 2020;39:e102675. Covery Story.
  • Gillich A, Zhang F, Farmer CG, Travaglini KJ, Tan SY, Gu M, Zhou B, Feinstein JA, Krasnow MA*, Metzger RJ*. Capillary cell-type specialization in the alveolus. Nature 2020;586:785-789.
  • Li J, Liang C, Yang KY, Huang X, Han MY, Li X, Chan VW, Chan KS, Liu D, Huang ZP, Zhou B*, Lui KO*. Specific ablation of CD4+ T-cells promotes heart regeneration in juvenile mice. Theranostics 2020;10:8018-8035.
  • Liu K, Jin H, Zhou B*. Genetic lineage tracing with multiple DNA recombinases: A user’s guide for conducting more precise cell fate mapping studies. J Biol Chem 2020;295:6413-6424.
  • Liu K, Tang M, Jin H, Liu Q, He L, Zhu H, Liu X, Han X, Li Y, Zhang L, Tang J, Pu W, Lv Z, Wang H, Ji H, Zhou B*. Triple-cell lineage tracing by a dual reporter on a single allele. J Biol Chem 2020;295:690-700. Cover Story.

2019

  • Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G, Ji H, Zhou B*. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet 2019;51:728-738. PDF
  • He L*, Han M, Zhang Z, Li Y, Huang X, Liu X, Pu W, Zhao H, Wang Q, Nie Y*, Zhou B*. Reassessment of c-Kit Cells for Cardiomyocyte Contribution in Adult Heart. Circulation 2019;140:164-166.
  • Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B*, Zhang H*. CCN1-Induced Cellular Senescence Promotes Heart Regeneration. Circulation 2019;139:2495-2498.
  • Li Y, Lv Z, He L, Huang X, Zhang S, Zhao H, Pu W, Li Y, Yu W, Zhang L, Liu X, Liu K, Tang J, Tian X, Wang Q-D, Lui KO, Zhou B*. Genetic Tracing Identifies Early Segregation of the Cardiomyocyte and Nonmyocyte Lineages. Circ Res 2019;125:343-355. Cover story.
  • Zhao H, Zhou B*. Dual genetic approaches for deciphering cell fate plasticity in vivo: more than double. Curr Opin Cell Biol 2019;61:101-109.
  • Li J, Yang KY, Tam RCY, Chan VW, Lan HY, Hori S, Zhou B, Lui KO*. Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. Theranostics 2019;9:4324-4341.
  • Yu W, Ma X, Xu J, Heumüller AW, Fei Z, Feng X, Wang X, Liu K, Li J, Cui G, Peng G, Ji H, Li J, Jing N, Song H, Lin Z, Zhao Y, Wang Z, Zhou B*, Zhang L*. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genet 2019;15:e1007977.

2018

  • Li Y, He L, Huang X, Issa Bhaloo S, Zhao H, Zhang S, Pu W, Tian X, Li Y, Liu Q, Yu W, Zhang L, Liu X, Liu K, Tang J, Zhang H, Cai D, Adams RH, Xu Q, Lui KO, Zhou B*. Genetic Lineage Tracing of Non-Myocyte Population by Dual Recombinases. Circulation 2018;138:793-805. (Editorial Comment) PDF
  • Tang J, Li Y, Huang X, He L, Zhang L, Wang H, Yu W, Pu W, Tian X, Nie Y, Hu S, Wang Q-D, Lui KO, Zhou B*. Fate Mapping of Sca1 Cardiac Progenitor Cells in the Adult Mouse Heart. Circulation 2018;138:2967-2969. (Editorial Comment)
  • Pu W, He L, Han X, Tian X, Li Y, Zhang H, Liu Q, Huang X, Zhang L, Wang QD, Yu Z, Yang X, Smart N, Zhou B*. Genetic Targeting of Organ-Specific Blood Vessels. Circ Res 2018;123:86-99.
  • Tang J, Zhang H, He L, Huang X, Li Y, Pu W, Yu W, Zhang L, Cai D, Lui KO, Zhou B*. Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult Heart. Circ Res2018;122:984-993. (Editorial Comment)
  • Zhang L, Issa Bhaloo S, Chen T, Zhou B*, Xu Q*. Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis. Circ Res 2018;122:1608-1624.
  • Zhang H, Lui KO, Zhou B*. Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration. Circ Res 2018;122:774-789.
  • Zhou B*, Wu SM*. Reassessment of c-Kit in Cardiac Cells: A Complex Interplay Between Expression, Fate, and Function. Circ Res 2018;123:9-11.
  • Li Y, Lui KO, Zhou B*. Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases. Nat Rev Cardiol 2018;15:445-456.
  • Li Y, Zhao H, Huang X, Tang J, Zhang S, Li Y, Liu X, He L, Ju Z, Lui KO, Zhou B*. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth. Cell Res 2018;28:775-778.
  • Liu K, Yu W, Tang M, Tang J, Liu X, Liu Q, Li Y, He L, Zhang L, Evans SM, Tian X*, Lui KO, Zhou B*. A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mensenchyme. Development 2018;145:dev167775.
  • Zhao H, Tian X, He L, Li Y, Pu W, Liu Q, Tang J, Wu J, Cheng X, Liu Y, Zhou Q, Tan Z, Bai F, Xu F, Smart N, Zhou B*. Apj+ Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target. Cell Rep 2018;25:1241-1254.e5.
  • He L, Li Y, Huang X, Li Y, Pu W, Tian X, Cai D, Huang H, Lui KO, Zhou B*. Genetic lineage tracing of resident stem cells by DeaLT. Nat Protoc 2018;13:2217-2246. Cover Story.

2017

  • He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B*. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med 2017;23:1488-1498. PDF
  • He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B*. Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest 2017;127:2968-2981.
  • Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang Q-D, Wu SM, Pu WT, Anderson RH, Zhou B*. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun 2017;8:759.
  • Zhang H, Huang X, Liu K, Tang J, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B*. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Res 2017;27:1157-1177.
  • He L, Zhou B*. Cardiomyocyte proliferation: remove brakes and push accelerators. Cell Res 2017;27:959-960.
  • Wang Y, Huang X, He L, Pu W, Li Y, Liu Q, Li Y, Zhang L, Yu W, Zhao H, Zhou Y, Zhou B*. Genetic tracing of hepatocytes in liver homeostasis, injury, and regeneration. J Biol Chem 2017;292:8594-8604.

2016

  • Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B*. Genetic lineage tracing identifies endocardial origin of liver vasculature. Nat Genet 2016;48:537-543. PDF
  • Zhang H, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Lui KO, Zhou B*. Endocardium Contributes to Cardiac Fat. Circ Res 2016;118:254-265.
  • Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov HM, Zhou B*. Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls. Circ Res 2016;118:1880-1893. (Cover story, Featured Article)
  • Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou Y, Huang P, Nie Y, Yan Y, Hui L, Lui KO, Zhou B*. Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration. Nat Commun 2016;7:13369.
  • Liu Q, Yang R, Huang X, Zhang H, He L, Zhang L, Tian X, Nie Y, Hu S, Yan Y, Zhang L, Qiao Z, Wang QD, Lui KO, Zhou B*. Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes. Cell Res 2016;26:119-130.
  • He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD, Zhou B*. Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovasc Res 2016;109:419-430.
  • Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B*. GATA4 regulates Fgf16 to promote heart repair after injury. Development 2016;143:936-949. (Highlighted Article)

2015

  • Liu Q, Huang X, Zhang H, Tian X, He L, Yang R, Yan Y, Wang QD, Gillich A, Zhou B*. c-kit+ cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair. Nat Med 2015;21:866-868. (Cover story)
  • Tian X, Pu WT, Zhou B*. Cellular Origin and Developmental Program of Coronary Angiogenesis. Circ Res 2015;116:515-530.
  • Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B*. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun 2015;6:6020.
  • Wei K, Serpooshan V, Hurtado C, Diez-Cunado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P*. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature 2015;525:479-485.

2014

  • Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B*. De novo formation of a distinct coronary vascular population in neonatal heart. Science 2014;345:90-94. (Featured Article) PDF
  • Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, Zhou B*. Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion. J Biol Chem 2014;289:18681-18692.

  • Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B*. Epicardium-to-fat transition in injured heart. Cell Res 2014;24:1367-1369. 

2013

  • Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans SM, Gittenberger-de Groot AC, Red-Horse K, Zhou B*. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res 2013;23:1075-1090. Cover Story, Research Highlight.
  • Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT*. Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci USA 2013;110:15395-15400.

2012

  • Zhou B*, Pu WT*. Genetic Cre-loxP Assessment of Epicardial Cell Fate Using Wt1-Driven Cre Alleles. Circ Res 2012;111:e276-e280.
  • von Gise A, Lin Z, Schlegelmilch K, Honor LB, Pan GM, Buck JN, Ma Q, Ishiwata T, Zhou B, Camargo FD, Pu WT*. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 2012;109:2394-2399.

2011

  • Zhou B*, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise A, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT*. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest 2011;121:1894-1904.
  • Smart N, Bollini S, Dube KN, Vieira JM, Zhou B, Davidson S, Yellon D, Riegler J, Price AN, Lythgoe MF, Pu WT, Riley PR*. De novo cardiomyocytes from within the activated adult heart after injury. Nature 2011;474:640-644.

Before 2010

  • Zhou B*, von Gise A, Ma Q, Hu YW, Pu WT*. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol 2010;338:251-261.
  • Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT*. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 2009;119:1462-1476.
  • Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT*. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 2008;454:109-113.
  • Zhou B, Ma FX, Liu PX, Fang ZH, Wang SL, Han ZB, Poon MC, Han ZC*. Impaired therapeutic vasculogenesis by transplantation of OxLDL-treated endothelial progenitor cells. J Lipid Res 2007;48:518-527.
  • Zhou B, Bi YY, Han ZB, Ren H, Fang ZH, Yu XF, Poon MC, Han ZC*. G-CSF-mobilized peripheral blood mononuclear cells from diabetic patients augment neovascularization in ischemic limbs but with impaired capability. J Thromb Haemost 2006;4:993-1002.
  • Zhou B, Zhao H, Yang RC, Han ZC*. Multi-dysfunctional pathophysiology in ITP. Crit Rev Oncol Hematol  2005;54:107-116.